| Characteristics | Details |
|---|---|
| Active Ingredient | Sildenafil Citrate |
| Available Dosages | Silagra 50 mg, Silagra 100 mg |
| Formulation | Tablet |
| Administration | Oral |
| Indications | Erectile Dysfunction |
| Learn More About Silagra | |
Pharmacokinetics
The pharmacokinetics of Silagra involves absorption, distribution, metabolism, and excretion. Silagra, primarily composed of sildenafil citrate, exhibits rapid absorption. Upon oral intake, peak plasma levels occur within 30 to 120 minutes. The bioavailability stands at approximately 40%. Fat-rich meals can slow the absorption rate.
Silagra disperses throughout the body, binding to plasma proteins at about 96%. This high binding rate indicates significant distribution in tissues. The metabolism process primarily occurs in the liver, utilizing cytochrome P450 enzymes, specifically CYP3A4. Metabolic transformations yield an active metabolite contributing to therapeutic effects.
The elimination half-life of sildenafil from Silagra is approximately 4 hours. The drug exits the body mainly through feces (approximately 80%) and urine (about 13%). Understanding pharmacokinetics helps optimize dosing strategies for maximum efficacy.
How should Silagra be used?
Silagra should be administered according to physician instructions. Typically, the standard dose is Silagra 50 mg, taken as needed. Patients can take it one hour before planned sexual activity. Adjustments depend on efficacy and tolerability, with a maximum recommended dose of Silagra 100 mg.
The frequency of administration should not exceed once daily. Swallow the tablet whole with water. Patients are advised to avoid consuming heavy or fatty meals around the time of dosage, as they may impede drug action.
Silagra is intended only for use by adults diagnosed with erectile dysfunction. Patients should not self-adjust the dose. Consistent use without medical guidance is discouraged.
Silagra Contraindications
Silagra is contraindicated in individuals with a known hypersensitivity to sildenafil or any component of the tablet. Patients using nitrates for chest pain or heart problems should avoid Silagra, as this combination can lead to a severe drop in blood pressure.
Patients with severe liver impairment or hypotension should not take Silagra. Individuals who have recently had a stroke, heart attack, or severe arrhythmia are also advised against its use.
Silagra is not intended for use in women or individuals under 18 years. It is also contraindicated in patients with hereditary degenerative retinal disorders, such as retinitis pigmentosa.
Cautions with other medicines
Silagra can interact with various medications, altering their effects. Concomitant use with nitrates, often used in angina treatment, can cause hypotension. Additionally, alpha-blockers, used in treating hypertension, may also interact, requiring dose adjustments.
Medications that inhibit cytochrome P450 enzymes, such as ketoconazole or erythromycin, can increase sildenafil concentrations. Protease inhibitors, used in HIV treatment, may amplify effects, necessitating careful management.
Patients using PDE5 inhibitors or other erectile dysfunction therapies should avoid Silagra. Consultation with healthcare providers is essential before combining with any medication.
Toxicity
The toxicity profile of Silagra includes potential adverse reactions. Common effects include headache, facial flushing, and indigestion. Some patients might experience dizziness, nasal congestion, or visual disturbances.
In rare instances, priapism, a painful erection lasting over four hours, may occur. Immediate medical intervention is required to prevent long-term damage. Cardiovascular complications, though rare, can manifest as myocardial infarction or stroke.
Patients should discontinue Silagra and seek medical attention if experiencing sudden vision loss, indicative of non-arteritic anterior ischemic optic neuropathy. Report any concerning symptoms to healthcare professionals promptly.
Silagra Over The Counter
Silagra is not available over the counter. It requires a prescription from a qualified healthcare provider. This restriction ensures appropriate use and mitigates risks associated with self-medication.
The necessity for a prescription allows physicians to evaluate underlying health conditions. They can assess potential contraindications and interactions, providing a tailored therapeutic approach.
Patients seeking Silagra should consult their healthcare providers. Medical assessments and professional guidance are paramount for safe and effective treatment.
| Indication | Details |
|---|---|
| Erectile Dysfunction | Helps achieve and maintain erection |
| Pulmonary Arterial Hypertension | Relaxes blood vessels in lungs |
- Consult healthcare providers before use
- Avoid alcohol and heavy meals when using Silagra
- Report any adverse effects to a physician immediately
Silagra, with its potential benefits, requires cautious use. Professional oversight is key to maximizing efficacy while minimizing risks. Always prioritize safety and consult healthcare providers for personalized advice.
Data source:
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